Chemotaxis: TorC before You Akt…
نویسندگان
چکیده
Chemotaxis uses intertwined signalling pathways, each individually dispensable. Recent work shows that Dictyostelium PKB/Akt can be spatially regulated independently of phosphatidylinositol (3,4,5)-trisphosphate via phosphorylation by TOR complex 2, placing this complex at the hub of chemotaxis.
منابع مشابه
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium.
Chemotaxis-competent cells respond to a variety of ligands by activating second messenger pathways leading to changes in the actin/myosin cytoskeleton and directed cell movement. We demonstrate that Dictyostelium Akt/PKB, a homologue of mammalian Akt/PKB, is very rapidly and transiently activated by the chemoattractant cAMP. This activation takes place through G protein-coupled chemoattractant ...
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ورودعنوان ژورنال:
- Current Biology
دوره 18 شماره
صفحات -
تاریخ انتشار 2008